Research FTIR spectrometer CONFOCHECK
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- In detail
Price is formed on each consignment of goods in stock
Minimum delivery: (a container wagon)
Terms of delivery: (of FCA, FOB, EXW or other agreement with the customer)
Payment terms: advance payment, partial payment, letter of credit
Country of origin: Russia and the world's leading companies.
Areas of use
- Determination of protein concentration
- Determination of conformational changes in the protein structure
- Dynamics of proteins (thermal conformational change)
- Monitoring Conformational changes in aggregation processes, precipitation and crystallization
- Determination of the secondary structure
- Quantitative analysis of solutes in aqueous samples (buffers, excipients, detergents)
Typical applications in the pharmaceutical industry:
- Research and development of drugs: Analysis of the effect of composition on protein stability
- Stability Study: Effect of pH, temperature, mutations, etc. on protein stability.
- Quality Control: The concentration Checking the correctness of the product (buffer filling) in the production process
- Research links: Analysis of the effect of protein due to the ligand structure of the protein
Main applications CONFOCHECK system - a study of conformational changes of the protein molecule, and determining the protein concentration in solution. Unique identification is based on an algorithm to find information on the spectra of proteins in a specialized database. This system allows for the quantitative analysis of proteins, as well as to investigate in detail the basic elements of protein secondary structure (alpha - helices, beta - sheets) in seconds. CONFOCHECK system consists of specialized cuvettes, providing the most accurate measurement of small volume samples (10 mg). In addition, this system allows you to qualitatively explore the membrane and freeze - dried proteins. Integrated thermostat carefully controls and maintains the temperature of the cuvettes in the range from 0 ° to 95 ° C,
AquaSpec TM is designed for the study of soluble and membrane proteins solubilized. The device is a flow cell with optical path length of about 7 micrometers, which is optimal for the aqueous solutions. Unlike traditional AquaSpec cell TM has greater efficiency and accuracy, allowing measurements to concentrations below 0.1 mg / ml and determine the smallest conformational changes. Using CONFOCHECK calibration, secondary structure and protein concentration of analyte can be determined immediately after the measurement (approximately 30 sec. ).
The processes of protein folding due to the influence of temperature was examined by BioATRCell II device. This system allows to study the changes in the secondary structure of the protein in a wide temperature range of 0 - 95 ° C, and to determine the melting point of the protein molecules. Furthermore, the system can monitor the clotting process and the aggregation of proteins. To analyze changes in protein conformation in solution depending on the pH or the concentration of the ligand used dialysis special cell that prevents the dissolution of the protein during its release from the low molecular weight impurities.
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